Implantable Fiber Optic Cannulae, Ø300 µm Core, 0.39 NA Fiber

Cannulae with Ø300 µm Core, 0.39 NA Multimode Fiber
Stainless Steel or Ceramic, Ø2.5 mm (FC) Ferrule
2 mm to 20 mm Cleaved Cannulae
Custom Versions Available

Ferrule Ends

CFMC13L20

20 mm Cleaved Fiber

CFM13L10

10 mm Cleaved Fiber

CFM13L05

5 mm Cleaved Fiber

Stainless Steel

Polished Ceramic

Ø2.5 mm

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Overview
Custom Cannula
Cannula Cleaving
Feedback
OG Selection Guide

Fiber Optic Cannula Selection Guide
Ø105 µm Core, 0.22 NA Fiber
Ø200 µm Core, 0.22 NA Fiber
Ø200 µm Core, 0.39 NA Fiber
Ø200 µm Core, 0.50 NA Fiber
Ø300 µm Core, 0.39 NA Fiber
Ø400 µm Core, 0.39 NA Fiber
Ø400 µm Core, 0.50 NA Fiber
Dual-Core Cannula
Cannulae with Diffuser Tip

Cannula Fiber Specifications
Fiber Type	FT300EMT
Wavelength Range (Click for Plot)	400 - 2200 nm
Fiber Core Diameter	300 ± 6 µm
Fiber Outer Diameter	325 ± 10 μm
Numerical Aperture	0.39
Cleaved Length Tolerance	±0.5 mm

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All Fiber Optic Cannulae and Optogenetics Patch Cables can be easily mated using an Interconnect or Mating Sleeve.

Features

Ø300 µm Core, 0.39 NA Fiber Optic Cannulae
Multiple Ferrule Options
- Ø2.5 mm (FC) Size
- Stainless Steel or Ceramic (Zirconia) Material
Various Fiber Lengths (2 - 20 mm) for a Variety of Applications
Contact Tech Support for Discount on High-Volume Purchases
Custom Versions Available (See Custom Cannula tab for Details)

Thorlabs' Implantable Fiber Optic Cannulae deliver light from an LED or laser light source to optically sensitive cells within a specimen. The cannulae consists of a ferrule and a length of protruding optical fiber that is typically surgically implanted using stereotaxic guidance. After implanting, the ferrule remains exposed; this provides an interface with our line of Optogenetics Equipment (see the OG Selection Guide tab for a full listing).

The cannulae sold on this page use a Ø300 µm, 0.39 NA fiber (item # FT300EMT) with a variety of ferrule and length options. Cannulae with Ø2.5 mm (FC) ferrules are easier to handle and provide a more robust connection that is ideal for larger specimens. Stainless steel ferrules are easy to score for better adherence when implanted and fixated with glue, while ceramic ferrules are lighter for reduced stress on the specimen.

Cannulae are available with a flat cleave to a pre-determined length (2, 5, 10, or 20 mm). An implant guide for the cannula sold on this page is also available below in packs of one or five.

Each cannula includes a protective cap that shields the ferrule end from dust and other hazards. Additional CAPF Fiber Caps are also sold separately. If the ferrule end becomes dirty from use, we offer a selection of inspection tools, as well as fiber optic cleaning products.

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Multiple fiber NAs are available across our optogenetics product line; cannulae with a 0.39 NA are sold on this page.

Mating Sleeve and Patch Cable Compatibility
The ferrule diameter of a patch cable and cannula is the key factor for physical compatibility with an interconnect and mating sleeve. Mixing stainless steel and ceramic ferrules should not introduce significant additional signal losses. Patch cables and cannulae using Ø2.5 mm (FC) ferrules are compatible with the ADAF1 mating sleeve and ADAF2 interconnect.

Numerical Aperture (NA)
For best performance, choose a patch cable and cannula with the same fiber core diameter and NA. Numerical Aperture (NA) defines the angle of the cone of light leaving the fiber tip at the end of the cannula and is a dimensionless quantity used by fiber manufacturers to specify the acceptance angle of an optical fiber. Cannulae with a lower NA provide a narrower cone of light at the tip, resulting in higher light intensity over a smaller area, while cannulae with a higher NA generate a wider cone of light that illuminates a larger area with lower intensity.

Custom Cannulae
Thorlabs also manufactures custom fiber optic cannulae. We can provide different fiber and/or ferrule types as well as different fiber lengths. Please see the Custom Cannula tab for details.

Optogenetics Product Family for In Vivo Applications

Thorlabs offers a wide variety of products designed to support in vivo optogenetics applications. Please visit the OG Selection Guide tab above to see a full listing of available products for different applications.

Optogenetics System Schematic

Related Optogenetics Products
Light Sources	Patch Cables (Ø300 µm Core)	Mating	Cannulae (Ø300 µm Core)	Accessories
Fiber-Coupled LEDs MM Laser, 473 nm	Standard	Interconnects Mating Sleeves	Standard	Implant Guides Cannula Holders

Custom Fiber Optic Cannula

Thorlabs offers custom cannulae with the following options. Place a quote request through the following form to receive a quote for your custom cannula order.

Custom Cannula Worksheet:

Fiber Type:
Ferrule Size:	Ø2.5 mm (FC) \| Ø1.25 mm (LC) (Custom length ferrules are also available. Contact Tech Support for details.)
Ferrule Material:	Stainless Steel \| Ceramic (Zirconia)
Fiber End:	Flat Cleave (tolerance of ± 0.5 mm) \| Scissor Cut
*Fiber Length (mm):**	Length is specified as in the diagram above, with tolerance as noted.
*Quantity:**
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Click to Enlarge
Figure 2: Pulling the Fiber with the BFG1 Bare Fiber Gripper

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Figure 1: Scribing the Fiber with the S90R Fiber Scribe

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Figure 3: Cleaved Fiber After Pulling

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Figure 4: Cleaved Fiber End, as Viewed Through the JEL10 Eye Loupe

Fiber Cleaving

A cleave, or precision cut, is used to ensure proper light propagation out of the fiber tip. Thorlabs' uncleaved cannula must be cleaved before use; a cleaved cannula can be cleaved again if a shorter fiber length is desired. We recommend the following procedure for cleaving the fiber end.

Required Materials

Uncleaved Fiber Optic Cannula
S90R Fiber Scribe
BFG1 Bare Fiber Gripper
KW32 Kimwipes™ Lint-Free Wipes
Isopropyl Alcohol
JEL10 Eye Loupe, EYL10X Premium Eye Loupe, or Microscope
FTDU Fiber Optic Disposal Unit (Recommended)

Cleaving Procedure

Clean the fiber end of the cannula using a lint-free wipe and isopropyl alcohol. Do not use acetone, as this will damage the TECS cladding on the exposed fiber.
Measure the desired length of fiber from the end of the ferrule. Mark this length on the fiber with a marker.
Place the cannula on a hard surface and secure the fiber end with a finger or tape, as shown in Figure 1.
Hold the cleaving tool perpendicular to the fiber and gently score the fiber as shown in Figure 1 to the right. Do not apply excessive pressure. The fiber should not break off at this point.
This step is critical in obtaining a good cleave. If the scribe is made too hard, the fiber will break instead of cleaving. If the scribe is too light, the fiber will not cleave.
Hold the cannula in one hand, and grip the fiber end with a bare fiber gripper in the other end as shown in Figure 2. Pull the fiber straight back until the fiber cleaves as shown in Figure 3. Dispose of the scrap fiber end in the FTDU or any medical or fiber sharps container.
If the fiber does not break with a moderate amount of tension, repeat steps 4-5 above applying slightly more pressure when scoring. Inspect the cleave using an eye loupe or microscope.

A good cleave will be flat across the fiber and perpendicular to the optic axis. There should be no ‘tag’ (i.e., protrusion) from the edge of the fiber. The region where the initial scribe was made may be visible. It should be less than 5% of the core diameter. Be patient as this process takes a little practice. Please be aware that it will be more difficult to achieve a high-quality cleave in large-core-diameter fibers compared to thinner fibers. A view of a properly cleaved fiber end as seen through a Thorlabs' JEL10 eye loupe is shown in Figure 4.

Click Here for a PowerPoint Illustrating This Procedure

Thorlabs also offers a full fiber connectorization manual, which covers fiber termination and connectorization, as well as bare fiber cleaving. It can be downloaded for free here, or a paper copy can be purchased here.

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Quick Links
Single-Site Stimulation
One Light Source to One Cannula Implant
Multilateral Stimulation
One Light Source to Two Cannula Implants Using Rotary Joint Splitter
One or Two Light Sources to Two Cannula Implants
One Light Source to Seven Cannula Implants
Two Light Sources into One Dual-Core Cannula Implant
Illumination
Fiber-Coupled LEDs and Drivers

Optogenetics Selection Guide

Thorlabs offers a wide range of optogenetics components; the compatibility of these products in select standard configurations is discussed in detail here. Please contact Technical Support for assistance with items outside the scope of this guide, including custom fiber components for optogenetics.

Single-Site Stimulation

One Light Source to One Cannula Implant

The most straightforward method for in vivo light stimulation of a specimen is to use a single fiber optic with a single LED light source. The single wavelength LED is powered by an LED driver, and then the illumination output is fiber-coupled into a patch cable, which connects to the implanted cannula. See the graphics and expandable compatibility tables below for the necessary patch cables and cannulae to create this setup. To choose the appropriate LED and driver, see below or the full web presentation.

Click on Each Component for More Information

Click for Details

Click to See Ø1.25 mm (LC) Ferrule Compatible Patch Cables, Cannulae, and Interconnects

Component Selection Table (Click Links for Item Description Popup)
Fiber Type		FG105LCA	FG200UCC	FT200EMT	FP200URT	FT400EMT	FP400URT
Fiber Type Specs	Core Diameter	105 µm	200 µm			400 µm
	Wavelength Range	400 - 2400 nm	250 - 1200 nm	400 - 2200 nm	300 - 1200 nm	400 - 2200 nm	300 - 1200 nm
	NA	0.22	0.22	0.39	0.50	0.39	0.50
Patch Cables^b	Standard FC/PC Input	M61L01	M86L005 M86L01	M83L01 MR83L01	M73L01	M99L01	M127L01
	Standard SMA905 Input	M63L01	M87L005 M87L01	M89L01 MR89L01	M95L01	M98L01	M125L01
	Rotary Joint FC/PC Input	-	-	RJPFL2	-	RJPFL4	-
	Rotary Joint SMA905 Input	-	-	RJPSL2	-	RJPSL4	-
Compatible Mating Sleeve/Interconnect		ADAL1, ADAL3, or ADAL4-5
Fiber Optic Cannulae^c	Ceramic 6.4 mm Long Ferrule	CFMLC21L02 CFMLC21L05 CFMLC21L10 CFMLC21L20 CFMLC21U-20	CFMLC22L02 CFMLC22L05 CFMLC22L10 CFMLC22L20 CFMLC22U-20	CFMLC12L02 CFMLC12L05 CFMLC12L10 CFMLC12L20 CFMLC12U-20	CFMLC52L02 CFMLC52L05 CFMLC52L10 CFMLC52L20 CFMLC52U-20	CFMLC14L02 CFMLC14L05 CFMLC14L10 CFMLC14L20 CFMLC14U-20	CFMLC15L02 CFMLC15L05 CFMLC15L10 CFMLC15L20
	Diffuser Tip (Ceramic 6.4 mm Long Ferrule)	-	-	CFDSB02 CFDSB05 CFDSB10 CFDSB20	-	-	-
	Ceramic 10.5 mm Long Ferrule	-	CFMXA02 CFMXA05 CFMXA10 CFMXA20	CFMXB02 CFMXB05 CFMXB10 CFMXB20	CFMXC02 CFMXC05 CFMXC10 CFMXC20	-	CFMXD02 CFMXD05 CFMXD10 CFMXD20
	Stainless Steel 6.4 mm Long Ferrule	CFML21L02 CFML21L05 CFML21L10 CFML21L20 CFML21U-20	CFML22L02 CFML22L05 CFML22L10 CFML22L20 CFML22U-20	CFML12L02 CFML12L05 CFML12L10 CFML12L20 CFML12U-20	CFML52L02 CFML52L05 CFML52L10 CFML52L20 CFML52U-20	CFML14L02 CFML14L05 CFML14L10 CFML14L20 CFML14U-20	CFML15L02 CFML15L05 CFML15L10 CFML15L20
Items are compatible with each other when they are comprised of the same fiber type and listed in the same column. Patch cables for single source to single implant applications are highlighted in green above. Choose a patch cable with an input that matches your light source. Available cannulae are highlighted in orange of the table above. Cannulae within the same column are interchangeable.

Click for Detials

Click to See Ø2.5 mm (FC) Ferrule Compatible Patch Cables, Cannulae, and Interconnects

Component Selection Table (Click Links for Item Description Popup)
Fiber Type		FG200UCC	FT200EMT	FP200URT	FT300EMT	FT400EMT	FP400URT
Fiber Type Specs	Core Diameter	200 µm			300 µm	400 µm
	Wavelength Range	250 - 1200 nm	400 - 2200 nm	300 - 1200 nm	400 - 2200 nm	400 - 2200 nm	300 - 1200 nm
	NA	0.22	0.39	0.50	0.39	0.39	0.50
Patch Cables^b	Standard FC/PC Input	M80L005 M80L01	M81L005 M81L01 MR81L01	M104L01	M56L005 M56L01	M82L005 M82L01	M128L01
	Standard SMA905 Input	M84L005 M84L01	M77L005 M77L01 MR77L01	M106L01	M58L005 M58L01	M79L005 M79L01	M126L01
	Rotary Joint FC/PC Input	-	RJAFF2 RJPFF2	-	-	RJPFF4	-
	Rotary Joint SMA905 Input	-	RJASF2 RJPSF2	-	-	RJPSF4	-
Compatible Mating Sleeve/Interconnect		ADAF1, ADAF2, or ADAF4-5
Fiber Optic Cannulae^c	Ceramic 10.5 mm Long Ferrule	CFMC22L02 CFMC22L05 CFMC22L10 CFMC22L20 CFMC22U-20	CFMC12L02 CFMC12L05 CFMC12L10 CFMC12L20 CFMC12U-20	CFMC52L02 CFMC52L05 CFMC52L10 CFMC52L20 CFMC52U-20	CFMC13L02 CFMC13L05 CFMC13L10 CFMC13L20	CFMC14L02 CFMC14L05 CFMC14L10 CFMC14L20 CFMC14U-20	CFMC54L02 CFMC54L05 CFMC54L10 CFMC54L20
Fiber Optic Cannulae^c	Stainless Steel 12.7 mm Long Ferrule	CFM22L02 CFM22L05 CFM22L10 CFM22L20 CFM22U-20	CFM12L02 CFM12L05 CFM12L10 CFM12L20 CFM12U-20	CFM52L02 CFM52L05 CFM52L10 CFM52L20 CFM52U-20	CFM13L02 CFM13L05 CFM13L10 CFM13L20	CFM14L02 CFM14L05 CFM14L10 CFM14L20 CFM14U-20	CFM15L02 CFM15L05 CFM15L10 CFM15L20
Items are compatible with each other when they are comprised of the same fiber type and listed in the same column. Patch cables for single source to single implant applications are highlighted in green above. Choose a patch cable with an input that matches your light source. Available cannulae are highlighted in orange of the table above. Cannulae within the same column are interchangeable.

Multilateral Stimulation

The ability to accurately and simultaneously direct light to multiple locations within a specimen is desired for many types of optogenetics experiments. For example, bilateral stimulation techniques typically target neurons in two spatially separated regions in order to induce a desired behavior. In more complex experiments involving the simultaneous inhibition and stimulation of neurons, delivering light of two different monochromatic wavelengths within close proximity enables the user to perform these experiments without implanting multiple cannulae, which can increase stress on the specimen.

Multilateral stimulation can be achieved with several different configurations depending on the application requirements. The sections below illustrate examples of different configurations using Thorlabs' optogenetics products.

Option 1: One Light Source to Two Cannula Implants Using Rotary Joint Splitter

Thorlabs' RJ2 1x2 Rotary Joint Splitter is designed for optogenetics applications and is used to split light from a single input evenly between two outputs. The rotary joint interface allows connected patch cables to freely rotate, reducing the risk of fiber damage caused by a moving specimen. See the graphic and compatibility table below for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

Click for Details

Click to See Ø1.25 mm (LC) Ferrule Components Recommended for Use with RJ2 Rotary Joint Splitter

Component Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Fiber Properties	Core Diameter	200 µm			400 µm
	Wavelength Range^a	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm
	NA	0.22	0.39	0.50	0.39	0.50
Input Patch Cables^b	Standard FC/PC Connectors	M122L01 M122L02 M122L05	M72L01 M72L02 M72L05	M123L01 M123L02	M74L01 M74L02 M74L05	M124L01 M124L02
Input Patch Cables^b	Hybrid SMA905 to FC/PC	M36L01	M75L01 M75L02	M129L01 M129L02	M76L01 M76L02	M131L01 M131L02
Rotary Joint		RJ2
Output Patch Cables	FC/PC to Ø1.25 mm (LC) Ferrule	M86L005 M86L01	M83L01 MR83L01	M73L01	M99L01	M127L01
Compatible Mating Sleeve/Interconnect		ADAL1, ADAL3, or ADAL4-5
Fiber Optic Cannulae^c	Ceramic 6.4 mm Long Ferrule	CFMLC22L02 CFMLC22L05 CFMLC22L10 CFMLC22L20 CFMLC22U-20	CFMLC12L02 CFMLC12L05 CFMLC12L10 CFMLC12L20 CFMLC12U-20	CFMLC52L02 CFMLC52L05 CFMLC52L10 CFMLC52L20 CFMLC52U-20	CFMLC14L02 CFMLC14L05 CFMLC14L10 CFMLC14L20 CFMLC14U-20	CFMLC15L02 CFMLC15L05 CFMLC15L10 CFMLC15L20
	Diffuser Tip (Ceramic 6.4 mm Long Ferrule)	-	CFDSB02 CFDSB05 CFDSB10 CFDSB20	-	-	-
	Ceramic 10.5 mm Long Ferrule	CFMXA02 CFMXA05 CFMXA10 CFMXA20	CFMXB02 CFMXB05 CFMXB10 CFMXB20	CFMXC02 CFMXC05 CFMXC10 CFMXC20	-	CFMXD02 CFMXD05 CFMXD10 CFMXD20
	Stainless Steel 6.4 mm Long Ferrule	CFML22L02 CFML22L05 CFML22L10 CFML22L20 CFML22U-20	CFML12L02 CFML12L05 CFML12L10 CFML12L20 CFML12U-20	CFML52L02 CFML52L05 CFML52L10 CFML52L20 CFML52U-20	CFML14L02 CFML14L05 CFML14L10 CFML14L20 CFML14U-20	CFML15L02 CFML15L05 CFML15L10 CFML15L20
Products in each column can be used with each other over the indicated wavelength range and is limited by the operating range of the RJ2 Rotary Joint Splitter. Individual products may be used outside this range; see product information for detailed specifications. Use a standard FC/PC patch cable to connect to an FC/PC-terminated light source. SMA905 to FC/PC hybrid patch cables should be used to connect to an SMA905-terminated light source. Available cannulae are highlighted in orange of the table above. Cannulae within the same column are interchangeable.

Click for Detials

Click to See Ø2.5 mm (FC) Ferrule Components Recommended for Use with RJ2 Rotary Joint Splitter

Component Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Fiber Properties	Core Diameter	200 µm			300 µm	400 µm
	Wavelength Range^a	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm
	NA	0.22	0.39	0.50	0.39	0.39	0.50
Input Patch Cables	Standard FC/PC Connectors	M122L01 M122L02 M122L05	M72L01 M72L02 M72L05	M123L01 M123L02	M56L005 M56L01	M74L01 M74L02 M74L05	M124L01 M124L02
Input Patch Cables	Hybrid SMA905 to FC/PC	M36L01	M75L01 M75L02	M129L01 M129L02	M58L005 M58L01	M76L01 M76L02	M131L01 M131L02
Rotary Joint		RJ2
Output Patch Cables	FC/PC to Ø2.5 mm (FC) Ferrule	M80L005 M80L01	M81L005 M81L01 MR81L01	M104L01	M56L005 M56L01	M82L005 M82L01	M128L01
Compatible Mating Sleeve/Interconnect		ADAF1, ADAF2, or ADAF4-5
Fiber Optic Cannulae^c	Ceramic 10.5 mm Long Ferrule	CFMC22L02 CFMC22L05 CFMC22L10 CFMC22L20 CFMC22U-20	CFMC12L02 CFMC12L05 CFMC12L10 CFMC12L20 CFMC12U-20	CFMC52L02 CFMC52L05 CFMC52L10 CFMC52L20 CFMC52U-20	CFMC13L02 CFMC13L05 CFMC13L10 CFMC13L20	CFMC14L02 CFMC14L05 CFMC14L10 CFMC14L20 CFMC14U-20	CFMC54L02 CFMC54L05 CFMC54L10 CFMC54L20
Fiber Optic Cannulae^c	Stainless Steel 12.7 mm Long Ferrule	CFM22L02 CFM22L05 CFM22L10 CFM22L20 CFM22U-20	CFM12L02 CFM12L05 CFM12L10 CFM12L20 CFM12U-20	CFM52L02 CFM52L05 CFM52L10 CFM52L20 CFM52U-20	CFM13L02 CFM13L05 CFM13L10 CFM13L20	CFM14L02 CFM14L05 CFM14L10 CFM14L20 CFM14U-20	CFM15L02 CFM15L05 CFM15L10 CFM15L20
Products in each column can be used with each other over the indicated wavelength range and is limited by the operating range of the RJ2 Rotary Joint Splitter. Individual products may be used outside this range; see product information for detailed specifications. Use a standard FC/PC patch cable to connect to an FC/PC-terminated light source. SMA905 to FC/PC hybrid patch cables should be used to connect to an SMA905-terminated light source. Available cannulae are highlighted in orange of the table above. Cannulae within the same column are interchangeable.

Option 2: One or Two Light Sources to Two Cannula Implants

If the intent is for one LED source to connect to two cannulae for simultaneous light modulation, then a bifurcated fiber bundle can be used to split the light from the LED into each respective cannula. For dual wavelength stimulation (mixing two wavelengths in a single cannula) or a more controlled split ratio between cannula, one can use a multimode coupler to connect one or two LEDs to the cannulae. If one cable end is left unused, the spare coupler cable end may be terminated by a light trap. See the graphic and compatibility table below for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

Click on Each Component Below for More Information

Click to see Compatible Fiber Bundles, Coupler/Splitters, Cannulae, and Interconnects

Part Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Core Diameter		105 µm	200 µm						400 µm
Wavelength Range		400 - 2200 nm^a	400 - 1200 nm^a		400 - 900 nm^a				400 - 2200 nm
NA		0.22	0.22		0.39		0.50		0.39
Ferrule Style^b		LC (Ø1.25 mm)	LC (Ø1.25 mm)	FC (Ø2.5 mm)	LC (Ø1.25 mm)	FC (Ø2.5 mm)	LC (Ø1.25 mm)	FC (Ø2.5 mm)	LC (Ø1.25 mm)	FC (Ø2.5 mm)
Bifurcated Y-Cable^c	FC/PC Input	-	BFYL1LF01	BFYF1LF01	BFYL2LF01	BFYF2LF01	-	-	BFYL4LF01	BFYF4LF01
Bifurcated Y-Cable^c	SMA905 Input	-	BFYL1LS01	BFYF1LS01	BFYL2LS01	BFYF2LS01	-	-	BFYL4LS01	BFYF4LS01
1x2 Multimode Coupler^c	FC/PC Input	TM105FL1B	TM200FL1B	TM200FS1B	TT200FL1A	TT200FS1A	TH200FL1A	TH200FS1A	-	-
1x2 Multimode Coupler^c	SMA905 Input	TM105SL1B	TM200SL1B	TM200SS1B	TT200SL1A	TT200SS1A	TH200SL1A	TH200SS1A	-	-
2x2 Multimode Coupler^c	FC/PC Input	-	-	-	TT200FL2A	TT200FS2A	-	-	-	-
2x2 Multimode Coupler^c	SMA905 Input	-	-	-	TT200SL2A	TT200SS2A	-	-	-	-
Compatible Mating Sleeve/Interconnect		ADAL1 ADAL3 ADAL34-5	ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5	ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5	ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5	ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5
Fiber Optic Cannulae^d	Ceramic 6.4 mm Long Ferrule	CFMLC21L02 CFMLC21L05 CFMLC21L10 CFMLC21L20 CFMLC21U-20	CFMLC22L02 CFMLC22L05 CFMLC22L10 CFMLC22L20 CFMLC22U-20	-	CFMLC12L02 CFMLC12L05 CFMLC12L10 CFMLC12L20 CFMLC12U-20	-	CFMLC52L02 CFMLC52L05 CFMLC52L10 CFMLC52L20 CFMLC52U-20	-	CFMLC14L02 CFMLC14L05 CFMLC14L10 CFMLC14L20 CFMLC14U-20	-
	Diffuser Tip (Ceramic 6.4 mm Long Ferrule)	-	-	-	CFDSB02 CFDSB05 CFDSB10 CFDSB20	-	-	-	-	-
	Ceramic 10.5 mm Long Ferrule	-	CFMXA02 CFMXA05 CFMXA10 CFMXA20	CFMC22L02 CFMC22L05 CFMC22L10 CFMC22L20 CFMC22U-20	CFMXB02 CFMXB05 CFMXB10 CFMXB20	CFMC12L02 CFMC12L05 CFMC12L10 CFMC12L20 CFMC12U-20	CFMXC02 CFMXC05 CFMXC10 CFMXC20	CFMC52L02 CFMC52L05 CFMC52L10 CFMC52L20 CFMC52U-20	-	CFMC14L02 CFMC14L05 CFMC14L10 CFMC14L20 CFMC14U-20
	Stainless Steel	CFML21L02 CFML21L05 CFML21L10 CFML21L20 CFML21U-20	CFML22L02 CFML22L05 CFML22L10 CFML22L20 CFML22U-20	CFM22L02 CFM22L05 CFM22L10 CFM22L20 CFM22U-20	CFML12L02 CFML12L05 CFML12L10 CFML12L20 CFML12U-20	CFM12L02 CFM12L05 CFM12L10 CFM12L20 CFM12U-20	CFML52L02 CFML52L05 CFML52L10 CFML52L20 CFML52U-20	CFM52L02 CFM52L05 CFM52L10 CFM52L20 CFM52U-20	CFML14L02 CFML14L05 CFML14L10 CFML14L20 CFML14U-20	CFM14L02 CFM14L05 CFM14L10 CFM14L20 CFM14U-20

Products in this column can be used with each other over the indicated wavelength range. Individual products may be used outside this range; see product information for detailed specifications.
LC components have a Ø1.25 mm ferrule end while FC components have a Ø2.5 mm ferrule end. Items listed in the same "Ferrule Style" column are compatible with each other.
Optogenetics products for one or two light sources to two cannula implant applications are highlighted in green above. Choose a component with an input that matches your light source.
Available cannulae are highlighted in orange of the table above. Cannule within the same column are interchangeable.

Option 3: One Light Sources to Seven Cannula Implants

If the intent is for one LED source to connect to seven cannulae for simultaneous light modulation, then a 1-to-7 fiber bundle can be used to split the light from the LED into each respective cannula. See the graphic and compatibility table below for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

Click on Each Component Below for More Information

Click to see Compatible Fiber Bundles, Coupler/Splitters, Cannulae, and Interconnects

Part Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Core Diameter		200 µm
Wavelength Range		250 - 1200 nm^a		400 - 2200 nm^a
NA		0.22 ± 0.02		0.39
Ferrule Style^b		LC (Ø1.25 mm)	FC (Ø2.5 mm)	LC (Ø1.25 mm)	FC (Ø2.5 mm)
1-to-7 Bundle^c	SMA905 Input	BF7L1LS1	BF7F1LS1	BF7L2LS1	BF7F2LS1
Compatible Mating Sleeve/Interconnect		ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5	ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5
Fiber Optic Cannulae^d	Ceramic 6.4 mm Long Ferrule	CFMLC22L02 CFMLC22L05 CFMLC22L10 CFMLC22L20 CFMLC22U-20	-	CFMLC12L02 CFMLC12L05 CFMLC12L10 CFMLC12L20 CFMLC12U-20	-
	Diffuser Tip (Ceramic 6.4 mm Long Ferrule)	-	-	CFDSB02 CFDSB05 CFDSB10 CFDSB20	-
	Ceramic 10.5 mm Long Ferrule	CFMXA02 CFMXA05 CFMXA10 CFMXA20	CFMC22L02 CFMC22L05 CFMC22L10 CFMC22L20 CFMC22U-20	CFMXB02 CFMXB05 CFMXB10 CFMXB20	CFMC12L02 CFMC12L05 CFMC12L10 CFMC12L20 CFMC12U-20
	Stainless Steel	CFML22L02 CFML22L05 CFML22L10 CFML22L20 CFML22U-20	CFM22L02 CFM22L05 CFM22L10 CFM22L20 CFM22U-20	CFML12L02 CFML12L05 CFML12L10 CFML12L20 CFML12U-20	CFM12L02 CFM12L05 CFM12L10 CFM12L20 CFM12U-20

Products in this column can be used with each other over the indicated wavelength range. Individual products may be used outside this range; see product information for detailed specifications.
LC components have a Ø1.25 mm ferrule end while FC components have a Ø2.5 mm ferrule end. Items listed in the same "Ferrule Style" column are compatible with each other.
Optogenetics products for one or two light sources to two cannula implant applications are highlighted in green above. Choose a component with an input that matches your light source.
Available cannulae are highlighted in orange of the table above. Cannule within the same column are interchangeable.

Two Light Sources into One Dual-Core Cannula Implant

For bilateral stimulation applications where the two cannulas need to be placed in close proximity (within ~1 mm), Thorlabs offers dual-core patch cables and cannulae that are designed for this specific application. Each core is driven by a separate light source, enabling users to stimulate and/or supress nerve cells in the same region of the specimen. See the graphic and compatibility table below for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

Click on Each Component for More Information

Part Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Core Diameter		200 µm
Wavelength Range		400 - 2200 nm
NA		0.39
Fiber Type		FT200EMT
Ferrule Style^a		FC (Ø2.5 mm)
Dual-Core Patch Cable	FC/PC Input	BFY32FL1
Dual-Core Patch Cable	SMA905 Input	BFY32SL1
Compatible Mating Sleeve/Interconnect		ADAF1 ADAF2 ADAF4-5
Dual-Core Fiber Optic Cannulae^c	Stainless Steel	CFM32L10 CFM32L20

FC components have a Ø2.5 mm ferrule end.
Patch cables for dual light source to single implant applications are highlighted in green above. Choose a patch cable with an input that matches your light source.
Available cannulae are highlighted in orange of the table above. Cannule within the same column are interchangeable.

LED Item #	Wavelength^a	Typical Opsin	Output Power^b	Color
M405F3^c	405 nm	mmilCFP, hcriGFP	3.7 mW	UV
M430F1	430 nm	ChR2	7.5 mW	Violet
M455F3	455 nm	ChIEF, bPAC	24.5 mW	Royal Blue
M470F4	470 nm	ChR2, ChR2-SFO	20 mW	Blue
M490F4	490 nm	Rh-CT, ChR2 (E123A)	2.8 mW	Blue
M505F3	505 nm	ChRGR, Opto-α1AR, Opto-β2AR	11.7 mW	Cyan
M530F3	530 nm	C1V1, VChR1	9.6 mW	Green
M565F3	565 nm	Arch, VChR1-SFO	13.5 mW	Lime
M595F2	595 nm	ChR2-SFO, eNpHR3.0	11.5 mW	Amber
M625F2	625 nm	ReChR	17.5 mW	Red

Click the link for a spectrum and raw data.
Typical output power measured with a Ø400 µm Core, 0.39 NA multimode fiber.
Precautions must be taken to prevent looking directly at the UV light and UV light protective glasses must be worn to avoid eye damage. Exposure of the skin and other body parts to UV light should be avoided.

Illumination

Click to Enlarge
M405F1

Fiber-Coupled LEDs and Drivers

Our fiber-coupled LEDs are ideal light sources for optogenetics applications. They feature a variety of wavelength choices and a convenient interconnection to optogenetics patch cables. Thorlabs offers fiber-coupled LEDs with nominal wavelengths ranging from 280 nm to 1050 nm. See the table to the right for the LEDs with the most popular wavelengths for optogenetics. A table of compatible LED drivers can be viewed by clicking below.

Click to See Compatible LED Drivers

Compatible Drivers^a	UPLED^b	LEDD1B^c	DC2200^b	DC4100^b,d,e	DC4104^b,d,e
Click Photos to Enlarge
Main Driver Features	USB-Controlled	Very Compact Footprint 60 mm x 73 mm x 104 mm (W x H x D)	Touchscreen Interface with Internal and External Options for Pulsed and Modulated LED Operation	4 Channels^d	4 Channels^d
LED Driver Current Output (Max)	1.2 A	1.2 A	LED1 Terminal: 10.0 A LED2 Terminal: 2.0 A^f	1.0 A per Channel	1.0 A per Channel
LED Driver Forward Voltage (Max)	8 V	12 V	50 V	5 V	5 V
Modulation Frequency	-	0 to 5 kHz (External)	20 to 100 kHz (Internal)^h DC to 250 kHz (External)^g,h	0 to 100 kHz (External)^h Simultaneous Across all Channels	0 to 100 kHz (External)^h Independently Controlled Channels
External Control Interface(s)	USB 2.0	Analog (BNC)	USB 2.0 and Analog (BNC)	USB 2.0 and Analog (BNC)	USB 2.0 and Analog (8-Pin)
EEPROM Compatible: Reads Out LED Data for LED Settings		-
LCD Display	-	-

Click on the item number link to view the complete presentation for each controller.
Automatically limits to LED's max current via EEPROM readout.
The preferred power supply (single channel or hub-based) depends on the end user's application and whether you already own compatible power supplies. To that end and in keeping with Thorlabs' green initiative, we do not ship the LEDD1B bundled with a power supply. This avoids the cost and inconvenience of receiving an unwanted single-channel supply if a hub-based system (Item # KCH301 or KCH601) would be more appropriate.
The DC4100 and DC4104 can power and control up to four LEDs simultaneously when used with the DC4100-HUB. The fiber-coupled LEDs on this page all require the DC4100-HUB when used with the DC4100 or DC4104.
These LED drivers have a maximum forward voltage rating of 5 V and can provide a maximum current of 1000 mA. As a result, they cannot be used to drive LEDs which have forward voltage ratings greater than 5 V. LEDs with maximum current ratings higher than 1.0 A can be driven using this driver, but will not reach full power.
The fiber-coupled LEDs sold above are compatible with the LED2 Terminal.
Small Signal Bandwidth: Modulation not exceeding 20% of full scale current. The driver accepts other waveforms, but the maximum frequency will be reduced.
The M565F3 and M595F2 LEDs produce light by stimulating emission from phosphor, which limits their modulation frequency range. These LEDs may not turn off completely when modulated above 10 kHz at duty cycles below 50%.

Ø2.5 mm (FC), Ceramic Cannulae

Item # Prefix	Image	Ferrule Size	Ferrule Length	Ferrule Material	Fiber Length	Cleave Type	Compatible Interconnect / Sleeve	Compatible Patch Cables	Compatible Implant Guide^a
CFMC13		Ø2.5 mm (FC)	10.5 mm	Ceramic	2, 5, 10, or 20 mm	Flat Cleave	ADAF2 Interconnect ADAF1 Mating Sleeve	M56 and M58 Patch Cables	OGF

Cannulae with 2 mm long fiber are not compatible with our implant guides.

Ø2.5 mm (FC), Stainless Steel Cannulae

Item # Prefix	Image	Ferrule Size	Ferrule Length	Ferrule Material	Fiber Length	Cleave Type	Compatible Interconnect / Sleeve	Compatible Patch Cables	Compatible Implant Guide^a
CFM13		Ø2.5 mm (FC)	12.7 mm	Stainless Steel	2, 5, 10, or 20 mm	Flat Cleave	ADAF2 Interconnect ADAF1 Mating Sleeve	M56 and M58 Patch Cables	OGF

Cannulae with 2 mm long fiber are not compatible with our implant guides.

Cannula Implant Guide

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Cross Section Drawing of OGF with CFM22L05 Cannula (Not Included)

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Implant Guide Assembly

Improves Adhesion and Stability During Implantation
Compatible with Ø2.5 mm Fiber Optic Cannulae with ≥5 mm Length
Ø5.1 mm Mounting Surface with Grooved Ring for Dental Cement
Lightweight Surgical Titanium Construction (0.11 g)
Weep Holes for Epoxy to Secure a Cannula
Compatible with Stereotaxic Cannula Holders

This Cannula Implant Guide is designed to provide guidance and stability for a fiber optic cannula during an implantation procedure. The bottom surface of each implant guide features a roughened surface and circular groove that increases the surface area available to dental cement and improves adhesion to the specimen. A 1.6 mm long protrusion on the implant guide helps stabilize the guide when implanted. The implant is constructed using lightweight surgical titanium (0.11 g) which can be sterilized prior to use. The OGF implant guide is compatible with our standard Ø2.5 mm cannulae (ceramic and stainless steel). When assembled, the length of the protruding fiber is reduced by 2 mm; therefore, the implant guide cannot be used with our 2 mm long cannulae. For convenience, the guide is offered in packs of one or five.

For best results when implanting a cannula, the OGF should be used with a cannula holder and stereotaxic guidance equipment. To affix the cannula within the implant guide, first insert the cannula into the receptacle of the implant guide (see drawing to the right). Then, add a small amount of cement or epoxy to the cannula via the two Ø0.8 mm weep holes. Then, insert the cannula and allow the glue to harden and secure the cannula in place; each implant guide has two Ø0.8 mm weep holes for excess glue. Finally, attach the cannula ferrule to an XCF cannula holder.